Ursodiol is primarily indicated for what type of health issue?

Ursodiol is primarily indicated for liver disease because it is a bile acid that aids in the management of certain liver conditions. Specifically, it is often used to dissolve cholesterol gallstones and treat conditions that impair bile flow, such as cholestasis. By improving bile flow and reducing the concentration of cholesterol in bile, Ursodiol can help protect the liver from damage and promote better liver function. This makes it a crucial medication for addressing various liver-related health issues.

The other options, such as joint pain, heart disease, and skin allergies, do not relate to the pharmacological effects or therapeutic use of Ursodiol, as it does not have indications for treating musculoskeletal issues, cardiovascular conditions, or dermatological problems. Thus, liver disease is the correct context for the use of this medication.